Esophageal malignant tumor
Conditions
Interventions
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.18 - 75 years old; 2.ASA I-III; 3.Scheduled minimally invasive esophagectomy (including minimally invasive Mckeown procedure, combined mediastinoscopy and laparoscopy); 4.The participants were fully aware of and voluntarily participated in this study. They were able to sign the informed consent form and voluntarily follow the procedures of this study.
Exclusion criteria
Exclusion criteria: 1.There are contraindications for epidural puncture: such as severe spinal or thoracic deformities, coagulation disorders, local infections, patients' refusal or inability to cooperate, and tumor bone metastasis, etc. 2.There are contraindications for the use of morphine and local anesthetics. 3.Patients with language communication disorders. 4.Patients with abuse of anesthetic drugs; 5.Severe respiratory diseases, sleep apnea syndrome, severe liver and kidney dysfunction, severe cardiovascular and cerebrovascular diseases (NYHA classification III - IV).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR-15 of postoperative day 3; | — |
Secondary
| Measure | Time frame |
|---|---|
| QoR-15 of postoperative day 1;Incidence of hypotension (systolic blood pressure <90 mmHg) within 24 hours postoperatively;The total number of remedial analgesic administrations within 3 days after the surgery.;mRNA Changes in Incision Skin at the Beginning and End of Surgery;Incidence of adverse reactions (respiratory depression, nausea and vomiting, dizziness, pruritus);QoR-15 of postoperative day 7;Length of Postoperative Hospital Stay;The most painful areas and their characteristics on postoperative days 1, 2, and 3;The incidence of anastomotic fistula during hospitalization;Rehabilitation quality of EORTC QLQ-C30 3 months after surgery;Changes in Immune Cells and Factors in Blood Before Surgery and on the First Postoperative Day;Time for Removal of Urinary Catheter After Surgery;Time of first flatulence after surgery;Total Hospitalization Costs;Postoperative pain scores at rest and during coughing on days 1, 2, 3, 5, and 7;The incidence of pulmonary complications during hospitalization;Time of first ambulation after surgery; | — |
Countries
China
Contacts
Public ContactFei Liu
West China Hospital of Sichuan University
Outcome results
None listed