None
Conditions
Interventions
The nasal spray of dexmedetomidine hydrochloride group:Before the first use, it is necessary to pre-spray 7 times to activate the nasal spray pump. Spray into the nasal cavity, each side of the nostri
Saline nasal spray group:Before the first use, it is necessary to pre-spray 7 times to activate the nasal spray pump. Spray into the nasal cavity, each side of the nostril should receive 1 spray, stay
Sponsors
Qingdao Municipal Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) ASA I-III grade; (2) Age range: 50 - 80 years old; (3) Gender: Open to both males and females; (4) BMI: 18.5 - 29 kg/m^2; (5) Patients scheduled to undergo knee and hip joint replacement surgery at Qingdao Municipal Hospital on an elective basis.
Exclusion criteria
Exclusion criteria: (1) Patients with poor compliance and inability to cooperate with the surgery; (2) Patients with severe organic diseases (coronary heart disease, bronchial asthma, severe hypertension, severe blood system dysfunction, liver and kidney function, electrolyte abnormalities) (3) Second-degree or higher atrioventricular conduction block, bradycardia (HR < 50 beats per minute), hypotension (SBP < 90 mmHg); (4) History of neurological diseases; chronic pain history; drug addiction and alcohol abuse; long-term use of opioid drugs history; (5) Patients allergic to the nasal spray of dexmedetomidine hydrochloride or its components; (6) Low educational level, unable to complete the survey of the relevant scoring scale; (7) History of nasal surgery, severe rhinitis, or abnormal nasal structure (such as deviation of the nasal septum); (8) Participated in other drug clinical trials within the past 4 weeks; (9) Infection at the puncture site, history of lumbar surgery, severe spinal injury, coagulation dysfunction or congenital developmental abnormalities (such as scoliosis), and other conditions not suitable for spinal anesthesia or contraindications to spinal anesthesia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The success rate of the first spinal anesthesia puncture;Satisfaction score during spinal anesthesia process; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ramsay score after using the nasal spray;The hemodynamic changes after using the nasal spray;The incidence of adverse events during the surgery;VAS pain score;Number of needle insertions, number of direction changes;Operation duration; | — |
Countries
China
Contacts
Public ContactXu Lin
Qingdao Municipal Hospital
Outcome results
None listed