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The omission of axillary dissection after neoadjuvant chemotherapy in node-positive breast cancer patients

The omission of axillary dissection after neoadjuvant chemotherapy in node-positive breast cancer patients

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500114409
Enrollment
Unknown
Registered
2025-12-11
Start date
2026-01-01
Completion date
Unknown
Last updated
2025-12-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Node-positive breast cancer

Interventions

study group:omission of axillary dissection

Sponsors

Beijing Cancer Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Patient between 18 and 70 years of age, invasive breast cancer confirmed by core biopsy; 2. cT1-3N1-2M0, axillary node positivity confirmed by core biopsy or needle cytology; 3. Placement of a clip in the proven positive axillary node befor NACT and converted to cN0 after NACT; 4. TAD successfully performed and pathology shows pN0; 5. Signed the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Axillary node positivity not pathologically confirmed before NACT; 2. Inflammatory breast cancer or M1 disease at presentation; 3. No clip placed befor NACT or remains cN1 after NACT; 4. TAD unsuccessful or pathology shows pN+; 5. Other physical or mental conditions deemed unfit for the study; 6. Pregnant or lactating women; 7. Informed consent form not signed.

Design outcomes

Primary

MeasureTime frame
Disease-free survival, DFS;—

Secondary

MeasureTime frame
ROC curve;—

Countries

China

Contacts

Public ContactXinguang Wang

Beijing Cancer Hospital

doctorwxg79@bjmu.edu.cn+86 10 88197839

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026