Parkinson's disease
Conditions
Interventions
control group(Sham Stimulation Group):Sham stimulation + conventional drug treatment
Electrical stimulation group:Transcranial electrical stimulation + conventional drug therapy
Sponsors
The Third Affiliated Hospital of Xinxiang Medical University
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. All cases meet the diagnostic criteria for Parkinson's disease (PD) of the UK Brain Bank Parkinson's Disease Society. 2. Aged between 40 and 75. 3. Parkinson's disease patients with Hoehn-Yahr (HY) stage 1 to 2.5, who can walk independently. 4. At the time of the experiment, the subjects had stable condition, clear consciousness, no language communication barriers, and could communicate fluently. 5. Before the start of the study, they received a stable dose of anti-Parkinson's medication for at least 2 weeks and maintained this dose during the treatment period. 6. No transcranial electrical stimulation (tDCS, tACS) was used within 3 months.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of stroke, head trauma, hydrocephalus, brain tumor, increased intracranial pressure, and intracranial surgery; 2. Patients with metal foreign bodies, pacemakers, heart stents, cochlear implants, etc. in their bodies; 3. Those who cannot cooperate with the rs-fMRI scan and the exercise intervention program; 4. Patients with alcohol dependence or central nervous system drug dependence; 5. Patients with alcohol dependence or central nervous system drug dependence.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Unified Parkinson's disease rating scale III, UPDRS III;electroencephalogram signal;Olfactory detection results; | — |
Secondary
| Measure | Time frame |
|---|---|
| Magnetic resonance data;Hamilton Anxiety;Electromyographic signal;Gait parameter;Hamilton Depression;King Parkinson's Pain Scale, KPPS;Pittsburgh Sleep Quality Index, PSQI;Parkinson's Disease Sleep Scale-2, PDSS-2;Scales for Outcomes in Parkinson’s Disease-Autonomic Dysfunction, SCOPA-AUT; | — |
Countries
China
Contacts
Public ContactHongxia Xin
The Third Affiliated Hospital of Xinxiang Medical University
Outcome results
None listed