Cognitive impairment
Conditions
Interventions
Tegileridine Group:Fifteen minutes before the end of surgery, 1 mg of tigecycline was administered intravenously. The PCIA solution was prepared by diluting 10 mg of tigecycline and 9 mg of granisetro
Control Group:Fifteen minutes before the end of surgery, 10 mg of morphine was administered intravenously. The PCIA solution was prepared by diluting 100 mg of morphine and 9 mg of granisetron to a to
Sponsors
Jiangsu Province People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Patients and their family members consent to participate in this study; (2) Patients scheduled for elective gastric or colorectal cancer surgery who consent to use a patient-controlled analgesia (PCA) pump postoperatively; (3) Age range of 65 to 80 years old; (4) Patients without severe hearing or visual impairments and who are literate.
Exclusion criteria
Exclusion criteria: (1) Patient or family members refuse to participate in the study; (2) History of ischemic stroke or transient ischemic attack (TIA); (3) History of myocardial infarction, or NYHA heart function classification of Class II or higher; (4) History of psychiatric disorders (e.g., schizophrenia, depression), cognitive impairment, epilepsy, or Parkinson's syndrome; (5) Abnormal liver function during the screening period: aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) > 1.5 × ULN and/or total bilirubin (TBIL) > 1.5 × ULN; (6) Abnormal renal function during the screening period: serum creatinine (Cr) > 1.5 × ULN; (7) Mini-Mental State Examination (MMSE) score below 23; (8) Current use of sedatives, antidepressants, or corticosteroids; (9) Alcoholism or substance abuse; (10) Inability to read, write, hear, speak, or communicate effectively.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium (POD); | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of delayed neurocognitive recovery ;Incidence of neurocognitive disorders (NCD);Postoperative pulmonary complications;Gastrointestinal reactions;VAS pain scores at 24 and 48 hours postoperatively;Incidence of rescue analgesia;Number of PCA bolus attempts;Consumption of Tegileridine or morphine; | — |
Countries
China
Contacts
Public ContactChun Yang
Jiangsu Province People's Hospital
Outcome results
None listed