Perioperative Management Optimization and Rehabilitation
Conditions
Interventions
Intervention Group:Postoperative pain control can be initiated immediately using a patient-controlled intravenous analgesia (PCIA) pump with a combination of esketamine and dexmedetomidine
Control Group :Postoperative pain control can be initiated immediately using a patient-controlled intravenous analgesia (PCIA) pump with a combination of sufentanil and dexmedetomidine
Sponsors
Lu'an Hospital of Anhui Medical University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Patients selected for laparoscopic hysterectomy under general anesthesia at our hospital; 2. Age 45–70 years old; 3. ASA classification I–III; 4. Normal cognitive and communication abilities; 5. Informed consent given and voluntary participation in the study.
Exclusion criteria
Exclusion criteria: 1. Refusal to participate in the experiment; 2. Allergy or adverse reaction to the drug being studied; 3. Severe cardiac, pulmonary, or organ dysfunction; 4. Chronic pain or recent use of analgesics, mental disorders, or alcohol/drug abuse; psychiatric disorders such as epilepsy or a history of mental illness (bipolar disorder, schizophrenia, etc.); 5. Severe hypertension: patients with grade 3 or higher hypertension or poorly controlled blood pressure; 6. High intraocular pressure: patients with glaucoma; 7. Significant organ dysfunction; 8. Myocardial infarction or congestive heart failure in the past 6 months; 9. Allergies to components of the study medication; 10. Terminal malignant tumors, communication disorders, or inability to correctly understand the investigator's questions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale;Ramsay Sedation Scale scores;State Anxiety Inventory (SAI)and Beck Depression Inventory (BDI);Pittsburgh Sleep Quality Index (PSQI) ;Quality of Recovery-40 (QoR-40) scale; | — |
Countries
China
Contacts
Public ContactZhonghou Xu; Wenxiu Wang
Lu'an Hospital of Anhui Medical University
Outcome results
None listed