Corneal Healing after Refractive Surgery
Conditions
Interventions
Fluorometholone group:Treatment was initiated on the first postoperative day with 0.1% Fluorometholone eye drops and 0.3% Tobramycin eye drops. Both medications were administered as one drop four time
Tobramycin and Dexamethasone group:Tobramycin and Dexamethasone eye drops were administered as one drop, four times daily. The medication was discontinued after one week of use.
Sponsors
Zigong First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: (1) Age between 18 and 40 years. (2) A preoperative spherical equivalent refraction between -10.0 D and -1.0 D. (3) Stable refraction for at least one year, with a change of = 470 µm, with an estimated residual stromal bed thickness of >= 280 µm postoperatively.
Exclusion criteria
Exclusion criteria: (1) Patients with impaired vital organ function, severe life-threatening systemic diseases, or psychiatric disorders. (2) Patients with autoimmune diseases (e.g., rheumatoid arthritis, hyperthyroidism) or diabetes mellitus. (3) Pregnant or lactating patients. (4) Patients with unstable refraction, a history of corneal trauma, or prior ocular surgery. (5) Patients with other ocular comorbidities, such as keratoconus, glaucoma, keratitis, retinal vasculitis, uveitis, or dry eye disease. (6) Patients with any systemic or local infectious disease within the past 3 months. (7) Individuals currently participating in other drug clinical trials, or those deemed by the investigator as unsuitable for the trial. (8) Patients who develop postoperative complications requiring additional ophthalmic medications. (9) Subjects with poor compliance, inability to complete the treatment and follow-up as planned, or those who voluntarily withdraw from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Corneal Densitometry; | — |
Secondary
| Measure | Time frame |
|---|---|
| Tear Inflammatory Cytokines;Quality of Vision; | — |
Countries
China
Contacts
Public ContactJun Zheng
Zigong First People's Hospital
Outcome results
None listed