Symptomatic chronic occlusion of intracranial arteries in patients
Conditions
Sponsors
The Second Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age greater than 18 years; 2. CT angiography or magnetic resonance angiography shows 100% occlusion of the cross-sectional area of the intracranial arteries; 3. The occlusion time is more than 4 weeks from the discovery to the present (confirmed by imaging, or inferred based on the responsible event); 4. Any of the following clinical symptoms occur: (1) ischemic stroke; (2) recurrent dizziness, discomfort, and sluggishness due to hypoperfusion; (3) transient blindness symptoms occur; (4) mild cognitive dysfunction; 5. The patient or legal representative signs a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Imaging confirmed intracranial hemorrhage; 2. mRS score >= 3 points; 3. Complicated with severe intracranial artery stenosis in the posterior circulation; 4. Pregnant or lactating women; 5. Severe dementia (MOCA score 1.5, increased bleeding risk due to abnormal coagulation factors; 9. Severe liver damage (ALT or AST > three times the upper limit of normal, liver cirrhosis), creatinine > 3.0 mg/dl (unless the patient is on dialysis); patients with combined heart or respiratory system failure; 10. Allergic or contraindicated to aspirin, clopidogrel, heparin, nickel-titanium alloy of stent components, local anesthetic or general anesthetic drugs; 11. Fatal allergy to contrast agents; if allergic but not fatal, it can be effectively prevented after careful assessment by a specialist before the operation; 12. Those with an expected survival of no more than 3 years, or those with concomitant intracranial or extracranial malignant tumors; 13. Already enrolled in other studies that may conflict with the current study; 14. Expected not to be able to complete follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Any stroke event or death within 30 days after enrollment;Within 30 days to 1 year after enrollment, ischemic stroke events in the area supplied by the responsible blood vessel; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neurological function assessment (mRS score) 90 days after enrollment;The incidence rates of hemorrhagic stroke, ischemic stroke and death within 30 days after enrollment;The incidence of ischemic stroke in the area supplied by the responsible blood vessels within one year after enrollment;Neurological function assessment (mRS score) one year after enrollment;All-cause mortality within one year after enrollment;The incidence of symptomatic cerebral hemorrhage within one year after enrollment;Rate of recanalization of occluded blood vessels within 1 year;One-year cognitive function; | — |
Countries
China
Contacts
Public ContactYangmei Chen
The Second Affiliated Hospital of Chongqing Medical University
Outcome results
None listed