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Effects of balance training combined with rTMS on electromyographic characteristics and motor cortex excitability in chronic ankle instability

Study on the Effects of Balance Training Combined with Transcranial Magnetic Stimulation on Peripheral-Central Coordination Regulation in Individuals with Chronic Ankle Instability

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500114384
Enrollment
Unknown
Registered
2025-12-11
Start date
2025-12-15
Completion date
Unknown
Last updated
2025-12-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic ankle instability

Interventions

waiting group:No exercise intervention, corresponding health education
However, the same index evaluation was completed at baseline and four weeks later.
Balance training group:The intervention plan of the balance training group includes 20 minutes of pseudo-TMS stimulation, 5-10 minutes of warm-up time (joint activity and stretching), sequential train
Joint intervention group:The combined intervention group combined basic therapy, balance training and transcranial magnetic stimulation (TMS).

Sponsors

Department of rehabilitation, Sichuan orthopedic hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 35 Years

Inclusion criteria

Inclusion criteria: 1. Patients aged 18–35 years with functional ankle instability; 2. BMI index 18.5–24.9 kg/m², no gender restriction; 3. Initial lateral ankle sprain within the past 12 months resulting in at least 3 days of immobilization and/or non-weight bearing; 4. History of "giving way" in the previously injured ankle, with recurrent sprains or sensations of instability (at least two episodes of "giving way" within 6 months prior to study enrollment); 5. Cumberland Ankle Instability Tool (CAIT) score = 11. 6. Right foot as dominant foot, with injury to the right foot.

Exclusion criteria

Exclusion criteria: 1. History of musculoskeletal surgery or any lower limb fracture; 2. Acute ankle injury or other injury within the past 3 months; 3. History of neurological disease or psychiatric disorders; 4. Exclude mechanical ankle instability (ligament rupture, avulsion fracture, etc.) by reviewing medical history, imaging findings, and patient complaints. 5. Clinical physical examination: Clinician performs physical examination (anterior/posterior drawer tests; valgus stress test) to rule out anatomical abnormalities; 6. Presence of metallic implants or metallic foreign bodies near the stimulation site; 7. History of epilepsy or convulsive seizures, or first-degree relatives with epilepsy; 8. Presence of cardiac pacemakers, neurostimulators, or cochlear implants; 9. Pregnant individuals or those with potential pregnancy; 10. History of unhealed skull fractures or intracranial lesions (e.g., tumors, infections, etc.).

Design outcomes

Primary

MeasureTime frame
Motor threshold;Motor evoked potential;Latent period of motor evoked potential;Root Mean Square;Integrated EMG;Co-Contraction Index;

Countries

China

Contacts

Public ContactZhang Xin

The Orthopedic Hospital of Sichuan Province

kangfuke2008@163.com+86 138 8070 8249

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026