Chronic Cancer Pain
Conditions
Interventions
Part 1 Cross-sectional Group:NA
Part 2: Depression Group:NA
Part 2: Non Depressive Group:NA
Sponsors
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Part 1: A Cross-Sectional Study on Quantitative EEG-Based Brain Function State Analysis in Chronic Cancer Pain Patients with Mood Disorders Inclusion Criteria: 1. Patients with a confirmed diagnosis of malignant tumor, presenting for the first time, assessed by an attending as requiring long-term opioid analgesic therapy, with a maximum VAS score >= 4 in the past 24 hours. 2. Age 18 years or older, with no specified upper age limit for the study. 3. Education level of primary school or higher, enabling full comprehension of the scales used in the study. 4. Awareness of their disease condition, indicating the patient has a certain understanding of their own condition and treatment plan. 5. Signed informed consent form. Patients included based on the above criteria will be further enrolled in: Part 2: A Prospective Cohort Study on the Impact of Mood Disorders on Pain Progression and Pharmacotherapeutic Efficacy in Chronic Cancer Pain Inclusion Criteria: 1. Patients with a confirmed diagnosis of malignant tumor, presenting for the first time at our hospital's Anesthesia and Pain Management Clinic, assessed by an attending physician as requiring long-term opioid analgesic therapy, with a maximum VAS score in the past 24 hours >= 4 points. 2. Age 18 years or older, with no specified upper age limit for the study. 3. Education level of primary school or higher, enabling full comprehension of the relevant scales used in the study. 4. Awareness of their disease condition, indicating the patient has a certain understanding of their own condition and treatment plan. 5. Signed informed consent form.
Exclusion criteria
Exclusion criteria: Part 1: A Cross-Sectional Study on Quantitative EEG-Based Brain Function State Analysis in Chronic Cancer Pain Patients with Mood Disorders Exclusion Criteria: 1. Patients with other chronic pain existing before the diagnosis of malignant tumor. 2. Presence of severe or poorly controlled systemic diseases (e.g., severe cardiovascular or respiratory diseases, decompensated chronic liver or kidney dysfunction). 3. Patients experiencing psychiatric symptoms directly caused by the malignant tumor. 4. History of drug abuse or analgesic medication misuse. Patients included based on the above criteria will be further enrolled in: Part 2: A Prospective Cohort Study on the Impact of Mood Disorders on Pain Progression and Pharmacotherapeutic Efficacy in Chronic Cancer Pain 1. Patients with other chronic pain conditions existing before the diagnosis of malignant tumor. 2. Patients with confirmed brain metastases from the malignant tumor or central nervous system involvement. 3. Allergy or contraindications to oral opioids, preventing standardized opioid analgesic therapy and follow-up according to clinical guidelines. 4. Expected survival period of less than 6 months. 5. Presence of severe or poorly controlled systemic diseases (e.g., severe cardiovascular or respiratory diseases, decompensated chronic liver or kidney dysfunction). 6. Participation in or ongoing participation in other clinical studies related to cancer pain within the past 3 months. 7. History of drug abuse or analgesic medication misuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantitative analysis of brain functional state depression index;Opioid Equivalent; | — |
Secondary
| Measure | Time frame |
|---|---|
| Prevalence of mood disorder;Scale assessment of cancer pain;Scale assessment of mood disorder;Quantitative analysis of brain functional state;Opioid Equivalent;Scale assessment of cancer pain;Adjuvant analgesic drugs; | — |
Countries
China
Contacts
Public ContactZhou Bowen
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College
Outcome results
None listed