General anesthesia for obese patients
Conditions
Interventions
Total body weight(TBW) Group:During anesthesia induction, ciprofol was administered via infusion pump based on the patients' total body weight (TBW).
Lean body weight(LBW) Group:During anesthesia induction, ciprofol was administered via infusion pump based on the patients' lean body weight (LBW).
Corrected body weight(CBW) Group:During anesthesia induction, ciprofol was administered via infusion pump based on the patients' corrected body weight (CBW).
Control Group:During anesthesia induction, ciprofol was administered via infusion pump based on the patients' total body weight (TBW).
Sponsors
Affiliated Hospital of North Sichuan Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years. 2. Assigned to one of two groups based on Body Mass Index (BMI):Experimental Group:** BMI >= 30.0 kg/m^2. Control Group:** BMI >= 18.5 kg/m^2 and < 25.0 kg/m^2. 3. American Society of Anesthesiologists (ASA) physical status II or III.
Exclusion criteria
Exclusion criteria: 1. Significant cardiopulmonary comorbidities; 2. Severe hepatic or renal impairment; 3. Hypersensitivity to ciprofol or its components; 4. Long-term use of benzodiazepines; 5. Predicted difficult airway; 6. Pre-existing psychiatric conditions impairing cooperation; 7. History of chronic alcohol abuse; 8. Diagnosis of myasthenia gravis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ciprofol Dosage; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to loss of consciousness (LOC), defined as MOAA/S <= 1;Hemodynamics;Injection pain;Respiratory depression; | — |
Countries
China
Contacts
Public ContactFaping Tu
Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College
Outcome results
None listed