Metabolic syndrome
Conditions
Interventions
Group 1:ED50 and ED95 of propofol during anesthesia induction in Class I obese patients
Group 2:ED50 and ED95 of propofol during anesthesia induction in Class II obese patients
Group 3:ED50 and ED95 of propofol during anesthesia induction in Class III obese patients
Sponsors
The First Affiliated Hospital of Jinan University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age: between 18 and 60 years old. Gender is not limited; 2. Preoperative gastroscopy for sedation/anesthesia; 3. Body mass index (BMI) : 30-50 kg/m2; 4. ASA classification: I-III; 5. agree and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with central nervous system disease, mental illness or language communication disorder; 2. Patients with a history of abnormal anesthesia recovery; 3. Patients allergic to propofol, remifentanil and other anesthetic drugs; 4. Alcohol dependence; 5. Llactating patients or preoperative long-term use of opioids or non-steroidal drugs; 6. Long-term use of ß-blockers and heart rate <50 beats/min; 7. Severe heart, brain, liver, kidney, respiratory dysfunction or dysfunction; 8. Subjects do not cooperate, or the investigator judges that it may be difficult for them to complete the study; 9. Other conditions judged by the investigator to be ineligible for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ED50 and ED95 of propofol during anesthesia induction ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Success rate of insertion;The incidence of hypoxia;Duration of hypoxia;Severe hypoxia;Awakening time;Recovery time of orientation;The incidence of body movement;The Brice questionnaire; | — |
Countries
China
Contacts
Public ContactMengxia Wang
The First Affiliated Hospital of Jinan University
Outcome results
None listed