pain
Conditions
Interventions
EOI group:Preoperative ultrasound-guided bilateral oblique subcostal transversus abdominis plane block with 0.375% ropivacaine, 20ml per side, combined with postoperative patient-controlled intravenou
Control group:Preoperative ultrasound-guided bilateral oblique subcostal transversus abdominis plane block with 0.9% saline, 20 ml per side, combined with postoperative patient-controlled intravenous
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age >= 60 years; 2. ASA physical status classification I–III; 3. Elective laparoscopic hepatectomy; 4. Sufficient cognitive capacity to complete postoperative follow-up; 5. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. History of allergy to local anaesthetics; 2. Infection at the injection site; 3. Concurrent surgery on organs other than the liver; 4. Chronic pain or chronic opioid use; 5. Presence of peripheral neuropathy or deficits; 6. Chronic sleep disorders with long-term use of sedative-hypnotic medications; 7. Patients with severe renal impairment, defined as serum creatinine =1.5 times the upper limit of normal or creatinine clearance <80 ml/min; 8. Patients with Child-Pugh class C or higher hepatic impairment; 9. Patients with cardiac insufficiency, defined as NYHA class III-IV.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Consumption of morphine equivalents within 24 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Morphine equivalent consumption;NRS pain scores at rest and during coughing;Intraoperative opioid consumption;Time to first postoperative rescue analgesia;The incidence and severity of pruritus, nausea, or vomiting ;Occurrence of complications associated with EOI;QoR-15 scores ;RCSQ scores;Length of Stay, LOS;Incidence of chronic pain at 3 months;Complications during hospitalization; | — |
Countries
China
Contacts
Public ContactGe Xiaodong
Zhongshan Hospital, Fudan University
Outcome results
None listed