Abdominal pain
Conditions
Interventions
Female TT group:Medium and long-chain propofol with a concentration of 10mg/ml was used as the test drug. The initial dose of medium and long-chain propofol was set at 3mg/kg. The induction dose of pr
Female TC group:Medium and long-chain propofol with a concentration of 10mg/ml was used as the test drug. The initial dose of medium and long-chain propofol was set at 3mg/kg. The induction dose of pr
Sponsors
Guangdong Provincial Maternal and Child Health Hospital
Eligibility
Sex/Gender
All
Age
5 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1.Age 5-12 years old, body mass index 14-24 kg/m^2; 2.Children undergoing gastroscopy under intravenous general anesthesia; 3.The affected children and their families understand the research procedures and purposes, and voluntarily participate in this research; 4.Receive medium-long-chain propofol induction and elective surgery.
Exclusion criteria
Exclusion criteria: 1.ASA >= level 3 2. Unable to cooperate with intravenous induction 3. Propofol allergy and other contraindications for propofol use 4. A syndrome that significantly affects cognitive development, with a total developmental quotient of less than 70 points calculated based on the Griffiths Mental Development Scale for individuals with obvious neurological defects or delayed development of the mental nervous system 5. There are genetic metabolic diseases such as congenital hypothyroidism, phenylketonuria, and methylmalonic acidemia 6. Abnormal liver and kidney functions 7.Participate in other clinical studies within 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ED50 of medium to long chain propofol for induction of pediatric general anesthesia gastroscopy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Perioperative Blood Pressure;Medium-long chain propofol dosage per kilogram of body weight per unit time;Perioperative Heart Rate; | — |
Countries
China
Contacts
Public ContactYun Wang
Guangdong Provincial Maternal and Child Health Hospital
Outcome results
None listed