Postoperative depression in patients undergoing gynecologic surgery
Conditions
Interventions
Esketamine Group:Esketamine (0.2 mg/kg) was administered intravenously during anesthesia induction.
Placebo Group:An equal volume of normal saline was administered concomitantly in the control group.
Sponsors
Shijiazhuang Fourth Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Age 18–45 years, BMI 18.5–28 kg/m²; 2. Diagnosed via ultrasound and clinical examination as: (1) Missed abortion / incomplete abortion (requiring curettage); (2) Ectopic pregnancy (primarily tubal, requiring laparoscopic or open surgery); 3. American Society of Anesthesiologists (ASA) physical status classification: Class I-II; 4. Voluntary signing of informed consent form, committing to complete all follow-up appointments.
Exclusion criteria
Exclusion criteria: 1. History of previous mental illnesses (e.g., depression, bipolar disorder, schizophrenia); 2. Allergy or contraindication to esketamine, propofol, sufentanil or related drugs; 3. Uncontrolled hypertension (systolic blood pressure >=160 mmHg or diastolic blood pressure >=100 mmHg), coronary heart disease, severe hepatic or renal insufficiency (ALT/AST > 3 times the upper limit of normal, Cr > 133 µmol/L), aneurysmal vascular disease, arteriovenous malformation, history of intracerebral hemorrhage, or recent cardiovascular events (e.g., myocardial infarction); 4. History of substance abuse (opioids, sedative-hypnotics) or alcohol dependence (>=14 standard drinks per week in the past 6 months); 5. Patients with untreated or inadequately treated hyperthyroidism; 6. Cognitive impairment or language communication disorders; 7. Participation in other clinical studies within the past 1 month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EPDS score change value; | — |
Secondary
| Measure | Time frame |
|---|---|
| HAMD-17 Moderate-to-Severe Depression Incidence;Spouse PHQ-9 score;PSQI score; | — |
Countries
China
Contacts
Public ContactXuefeng Cui
Shijiazhuang Fourth Hospital
Outcome results
None listed