None
Conditions
Interventions
40 µg/kg group:The dosage of oliceridine for anesthesia is 40 µg/kg
45 µg/kg group:The dosage of oliceridine for anesthesia is 50 µg/kg
50 µg/kg group:The dosage of oliceridine for anesthesia is 50 µg/kg
55 µg/kg group:The dosage of oliceridine for anesthesia is 55 µg/kg
60 µg/kg group:The dosage of oliceridine for anesthesia is 60 µg/kg
Sponsors
Guangzhou women and children's medical center
Eligibility
Sex/Gender
All
Age
2 Years to 6 Years
Inclusion criteria
Inclusion criteria: 1. Children undergoing laparoscopic hernia repair under general anesthesia with a laryngeal mask 2. ASA classification I-II 3. Aged 2-6 years old
Exclusion criteria
Exclusion criteria: 1. Children with allergies to the components of oliceridine; children with severe thrombocytopenia or gastrointestinal ulcers; 2. Children who used analgesic-sedative drugs, antiemetic drugs, and anti-itch drugs within 24 hours before surgery; 3. Children with symptoms of acute upper respiratory tract infection before surgery; 4. Children with a history of bronchial asthma; 5. Children with severe sleep apnea syndrome or arrhythmia; 6. Children with a history of abnormal recovery from surgical anesthesia; children with preoperatively assessed existing or potentially difficult airways; 7. Renal impairment (BUN and/or Cr > upper limit of normal value); liver function impairment (ALT and/or AST > 1.5 times the upper limit of normal value) 8. Children with relevant mental or neurological diseases, making it difficult to evaluate the analgesic effect; 9. Children with a history of chronic pain or long-term use of painkillers; 10. Children with other conditions that the researchers consider unsuitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| LMA insertion conditions; | — |
Secondary
| Measure | Time frame |
|---|---|
| Bispectral Index(BIS);The Nociception Index(qNOX);postoperative nauese and vomiting;Heart rate, blood pressure; | — |
Countries
China
Contacts
Public ContactYong Zhang
Guangzhou women and children's medical center
Outcome results
None listed