Acute-on-chronic liver failure with sepsis
Conditions
Interventions
Observation group:None
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Simultaneously meet the diagnostic criteria for acute-on-chronic liver failure (ACLF) and sepsis. The diagnostic criteria for ACLF refer to the "Guidelines for the Diagnosis and Treatment of Liver Failure (2024 Edition)" and the Chinese Severe Hepatitis B Study Group (COSSH-ACLF) standards: on the basis of chronic liver disease (with or without cirrhosis), acute deterioration of liver function caused by various triggers, accompanied by liver and/or extrahepatic organ failure, with total bilirubin (TBIL) >= 12 mg/dL (205 µmol/L) and PT-INR >= 1.5; the diagnostic criteria for sepsis refer to the International Sepsis 3.0 standards, that is, infection with a SOFA score > 2; 2. Have received at least one session of artificial liver support therapy; Applicable to Part One: those with relatively complete records; applicable to Part Two: individuals who voluntarily participate in this study and are willing to sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Age < 18 years; 2.Pregnancy; 3.Malignancy; 4.Declined to participate in the clinical study; 5.Hospital stay < 24 hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All-cause death; | — |
Secondary
| Measure | Time frame |
|---|---|
| Baseline characteristics (including age, gender, height, weight);Initial Laboratory and Artificial Liver Treatment Examination Results (Before and After Hospitalization) - White Blood Cells, Neutrophil Count, Lymphocyte Count, Red Blood Cells, Hemoglobin, Platelet Count, ALT, AST, TBIL, ALB, BUN, SCr, UA, Sodium Ion, Potassium Ion, Chloride Ion, Blood Lactic Acid, CRP, PCT, IL-6; | — |
Countries
CHina
Contacts
Public ContactKunping Cui
West China Hospital of Sichuan University
Outcome results
None listed