Ischemic stroke
Conditions
Interventions
Omega-3 group:Nasal feeding/oral administration, 7 capsules twice a day from day 1-7, 4 capsules twice a day from day 8-14, 3 capsules once a day from day 15-90.
Corn oil group:Nasal feeding/oral administration corn oil, 7 capsules twice a day from day 1-7, 4 capsules twice a day from day 8-14, 3 capsules once a day from day 15-90.
Sponsors
Guangdong Medical University Affiliated Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age range: 18-80 years old; 2. The time from onset to randomization is within 12 hours; 3. Based on clinical symptoms or imaging examinations, it is preliminarily judged as anterior circulation large vessel occlusion stroke. CTA/MRA/DSA confirms occlusion of the intracranial segment of the internal carotid artery and the M1 and M2 segments of the middle cerebral artery; 4. NIHSS score >= 6 points; 5. Alberta Stroke Early Diagnosis Program (ASPECTS) score 2-6 points; 6. The patient underwent endovascular treatment; 7. The patient or family member signs a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Confirmed intracranial hemorrhage through computed tomography (CT) or magnetic resonance imaging (MRI) of the skull; 2. MRS score >= 2 points before onset; 3. Pregnant or lactating women; 4. Omega-3 PUFAs allergy; 5. Currently participating in other clinical trials; 6. Systolic blood pressure>185mmHg or diastolic blood pressure>110mmHg, and oral antihypertensive drugs cannot control it; 7. Genetic or acquired bleeding constitution, lack of anticoagulant factors; Or have taken oral anticoagulants with INR>1.7; 8. Blood glucose22.2mol/L (400mg/dl), platelet count220 µ mol/L (2.5mg/dl)); Late stage of any disease leading to an expected life expectancy of less than 6 months; Intracranial aneurysm (diameter greater than 3mm), arteriovenous malformation; Brain tumors with space occupying effects in imaging; Systemic infectious diseases; Expected inability to complete follow-up
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| National Institute of Health stroke scale,NIHSS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Modified Rankin Scale, mRS;Modified Rankin Scale, mRS;A reduction of 4 points or more on NIHSS;An increase of 4 points or more on the NIHSS;EQ-5D ;Conversion of intracranial hemorrhage within 24 hours; | — |
Countries
China
Contacts
Public ContactWangtao Zhong
Guangdong Medical University Affiliated Hospital
Outcome results
None listed