Lower extremity fracture in the elderly
Conditions
Interventions
Preoperative Dexmedetomidine Group:Infusion is initiated 15 minutes before neuraxial anesthesia puncture at a dose of 0.5 µg/kg, with a duration of at least 10 minutes.
Intraoperative Dexmedetomidine Group:Infusion is initiated 15 minutes before skin incision at a dose of 0.5 µg/kg, with a duration of at least 10 minutes.
Control Group:An equivalent volume of 0.9% sodium chloride injection was infused concurrently, with the infusion rate and duration matching those of the experimental group.
Sponsors
Rugao People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Patients scheduled to undergo lower limb fracture surgery under neuraxial anesthesia; (2) Age >= 65 years; (3) Ability to complete MMSE, MoCA, and VAS assessments; (4) Both the patient and family members provide written informed consent to participate in the study; (5) ASA physical status classification ?–?.
Exclusion criteria
Exclusion criteria: (1) The patient or family members refuse to participate in the study; (2) Comorbid organic brain diseases, such as traumatic brain injury, intracranial hematoma, or congenital brain malformations; (3) Patients with dementia or known psychiatric disorders; (4) Individuals with aphasia or hearing impairment; (5) Patients with a known allergy to the study drug; (6) Preoperative severe sinus bradycardia (<50 beats per minute); (7) Patients with hepatic dysfunction (Child-Pugh class B or C) or renal dysfunction (uremic stage or requiring preoperative dialysis); (8) Patients who do not sign the informed consent form or are lost to follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of delirium within 3 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini-Mental State Examination Score;Leeds Sleep Evaluation Questionnaire;Visual Analog Scale (VAS) pain score;Activities of Daily Living Score;Cerebral function parameters (Cerebral Oxygen Saturation, rSO?, and Bispectral Index, BIS);Hemodynamics; | — |
Countries
China
Contacts
Public ContactXiaolin Yang
Rugao People's Hospital
Outcome results
None listed