Rib fracture
Conditions
Interventions
Trial group:Bupivacaine liposome 20ml(266mg)
Sponsors
Beijing Jishuitan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. Subjects who can understand the procedures and methods of the clinical trial, provide full informed consent, and voluntarily participate, with the informed consent form signed by the subject or their legal guardian. 2. Patients scheduled to undergo internal fixation surgery for multiple rib fractures under general anesthesia. 3. Age: 18–64 years. 4. ASA: I–III
Exclusion criteria
Exclusion criteria: 1. BMI >= 35 kg/m^2 or BMI <= 15 kg/m^2; 2. Bilateral rib fractures; 3. Combined multiple injuries: such as limb injuries, cranial or cerebral injuries, thoracoabdominal combined injuries, etc.; 4. History of chronic pain (pain lasting more than three months other than the current surgical indication, such as trauma, herpes zoster, trigeminal neuralgia, etc.); 5. Pregnant or lactating women, currently breastfeeding, or who have given birth within the past six months even without artificial breastfeeding; 6. Underwent major surgery within 3 months (90 days) prior to dosing, or underwent surgery that may significantly affect the pharmacokinetics or safety evaluation of the study drug; 7. Excessive alcohol or drug abuse, long-term use of opioid medications; 8. History of allergy to local anesthetics; 9. Coagulation dysfunction; 10. Infection at the puncture site; 11. Severe cardiovascular, respiratory, or neurological diseases; 12. Inability to understand or use the pain scale prior to surgery; 13. Patient refusal.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The VAS score 48 hours after the operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS score;Area under the pain intensity score-time curve within 72 hours postoperatively (AUC 0–72 h);Ultrasound assessment of diaphragmatic excursion and respiratory function (tidal volume, forced vital capacity);Blood gas analysis;Mean arterial pressure;Heart rate;Oxygen saturation;Respiratory rate;Quality of postoperative recovery;Opioid Consumption;Length of Stay;Satisfaction Score for Postoperative Analgesia;Nerve block–related complications; | — |
Countries
China
Contacts
Public ContactZhao Yaoping
Beijing Jishuitan Hospital, Capital Medical University
Outcome results
None listed