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Mechanistic Investigation of Gut Microbial Signatures in Intestinal Fibrosis of Inflammatory Bowel Disease: A Multi-Omics Perspective

Mechanistic Investigation of Gut Microbial Signatures in Intestinal Fibrosis of Inflammatory Bowel Disease: A Multi-Omics Perspective

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500114291
Enrollment
Unknown
Registered
2025-12-10
Start date
2025-12-20
Completion date
Unknown
Last updated
2025-12-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Crohn's disease

Interventions

Non-inflammatory bowel disease control group:None
Inflammatory Bowel Disease Stricture Group:None
Non-stricturing inflammatory bowel disease group:None

Sponsors

The First Affiliated Hospital with Nanjing Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Diagnosed with inflammatory bowel disease; 2. Fibrotic stricture confirmed through Masson staining of the surgical specimen.

Exclusion criteria

Exclusion criteria: Pregnancy, autoimmune diseases, blood system diseases, malignant tumors, chronic liver and kidney diseases, as well as severe heart, brain, and lung diseases.

Design outcomes

Primary

MeasureTime frame
Intestinal fibrosis level;Gut microbiota composition;—

Secondary

MeasureTime frame
Changes in metabolites;—

Countries

China

Contacts

Public ContactHongjie Zhang

The First Affiliated Hospital with Nanjing Medical University

hjzhang06@163.com+86 139 5197 5918

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026