Thyroid eye diseas
Conditions
Interventions
control group:placebo
experimental group:L-arginine supplementation
Sponsors
Eye Hospital, Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
30 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 30-60 years old, regardless of gender; 2. TAO patients with MD value 4.8; 4. At least one eye has abnormal Qcsf; 5. In good physical condition and able to meet follow-up requirements; 6. After fully understanding the safety of the research project, willing to actively cooperate with the research and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with ocular diseases that may affect visual function, such as corneal ulcer, cataract, retinal vascular disease, retinal detachment, and other optic nerve diseases; 2. Patients with acute TAO and those with incomplete eyelid closure; 3. History of brain tumor, brain trauma, or cerebrovascular disease; 4. History or family history of neurological disease or mental illness; 5. Patients with poorly controlled diabetes or severe systemic diseases such as severe heart, liver, or renal insufficiency; 6. Exclusion of orbital apex crowding by MRI/HRCT examination; 7. Women who are pregnant, lactating, or have plans to become pregnant within the past six months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Retinal capillary density;visual acuity;qCSF; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood glucose, glycated hemoglobin, blood lipid profile, arginine metabolism profile;Orbital Imaging;clinical activity score;exophthalmos;blood pressure;ocular pressure;visual field; | — |
Countries
China
Contacts
Public ContactYunhai Tu
Eye Hospital, Wenzhou Medical University
Outcome results
None listed