Neuropathic Pain
Conditions
Interventions
Trial group:Sequential rTMS stimulation targeting the dorsolateral prefrontal cortex (DLPFC) followed by the primary motor cortex (M1)
Control group:All participants received M1 stimulation combined with sham stimulation of the DLPFC using the coil tilting method
all subjects underwent a 5-day treatment course and were assessed multidimensionally using clinical scales and TMS-EEG techniques at baseline, post-treatment, and at a 1-month follow-up.
Sponsors
Hangzhou Third People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age over 18, gender not limited; 2. Meets the diagnostic criteria for neuropathic pain established by the International Association of Pain Societies (IASP); 3. Within one week prior to enrollment, the average daily pain intensity rating scale (NRS) score was >= 4 points; 4.Having normal understanding and communication skills, able to complete research related questionnaire filling and evaluation processes; 5.Voluntarily participate in this study and sign a written informed consent form approved by the ethics committee.
Exclusion criteria
Exclusion criteria: 1.Taboos for TMS examination; 2.Individuals who have previously suffered from mental illnesses, aphasia, or dementia; 3. Individuals with severe cardiopulmonary dysfunction, extreme weakness, and inability to cooperate with rehabilitation assessment and treatment; 4.Suffering from other diseases that may interfere with research results, such as epilepsy (including idiopathic epilepsy, symptomatic epilepsy, even if there have been no seizures in the past 5 years) or a family history of epilepsy. 5.Pregnant or lactating women; 6.Patients who are currently participating in other clinical studies or using other experimental drugs for treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neuroelectrophysiology;Numerical Rating Scale for Pain Intensity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neuropsychology; | — |
Countries
China
Contacts
Public ContactYan Yongxing
Hangzhou Third People's Hospital
Outcome results
None listed