pain
Conditions
Interventions
Sufentanil group:Use sufentanil as an analgesic during surgery
Oliceridine group:Use Oliceridine as an analgesic during surgery
Sponsors
The First Affiliated Hospital of University of Science and Technology of China
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Selecting patients diagnosed with uterine fibroids or ovarian cysts before surgery for gynecological laparoscopic surgery 2.Expected surgery time exceeds 1 hour 3.American Society of Anesthesiologists (ASA) classification I-II 4.Age range: 18-65 years old
Exclusion criteria
Exclusion criteria: 1. Body weight > 75 kg 2. Presence of severe organic pathology (coronary heart disease, bronchial asthma, severe hypertension, significant haematological dysfunction, marked abnormalities in hepatic or renal function, or electrolyte imbalance) 3. Atrioventricular block, bradycardia (HR < 50 beats per minute), hypotension (SBP < 90 mmHg) 4. History of neurological disorders; chronic pain; substance dependence or alcohol abuse; prolonged opioid use history 5. History of opioid allergy 6. Patients with delayed gastric emptying or gastroparesis; impaired intestinal motility or intestinal obstruction 7. Participants enrolled in other clinical trials 8. Patients with other conditions deemed ineligible by the investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative NRS scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of QT interval prolongation; | — |
Countries
China
Contacts
Public ContactWang Sheng
The First Affiliated Hospital of University of Science and Technology of China
Outcome results
None listed