Ischemic stroke
Conditions
Interventions
Inhalational Anesthesia Group:Sevoflurane-based Inhalational Anesthesia
Total intravenous anesthesia Group:Propofol-based Intravenous Anesthesia
Sponsors
The Second Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years and <= 90 years (inclusive) ; 2. Occlusion of large vessels in the anterior cerebral circulation (internal carotid artery, or M1/M2 segments of the middle cerebral artery) confirmed by computed tomography angiography (CTA) or magnetic resonance angiography (MRA) ; 3. Ability to live independently before stroke, with an estimated pre-stroke modified Rankin Scale (mRS) score of 0–2 ; 4. Provision of informed consent by the patient and their legal guardian (if applicable)..
Exclusion criteria
Exclusion criteria: 1. Pre-existing vascular diseases that preclude the current endovascular treatment, such as aortic dissection, aneurysm, and other analogous conditions; 2. National Institutes of Health Stroke Scale (NIHSS) score 30; 3.Patients with ASPECTS<=6; 4. Patients with pre-existing intracranial hemorrhage; 5. Pre-existing neurological or psychiatric disorders that may interfere with the assessment of postoperative neurological function; 6. Patients with a history of allergy to contrast media or anesthetics; 7. Patients with comorbid infective endocarditis; 8. Patients with intracranial space-occupying lesions or tumors confirmed by computed tomography (CT) or magnetic resonance imaging (MRI); 9. Patients concurrently participating in other clinical trials;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients with modified Rankin Scale score <= 2; | — |
Secondary
| Measure | Time frame |
|---|---|
| The ordinal scores on the modified Rankin Scale (mRS) ;National Institutes of Health Stroke Scale score;Score on the modified Thrombolysis in Cerebral Infarction Scale immediately after endovascular therapy;Global health status assessed by the Patient-Reported Outcomes Measurement Information System Global-10;Health-related quality of life assessed by the EuroQol-5 Dimensions questionnaire;Anxiety and depression symptoms ;All-cause mortality at 3 months post-operation;Major Vascular Events;Incidence of major in-hospital complications;Incidence of symptomatic intracranial hemorrhage within 48 hours post-operation;Rate of decompressive craniectomy performed;Duration of assisted ventilation;Total length of hospital stay;Length of stay in the Intensive Care Unit;All-cause mortality at 30 days post-operation; | — |
Countries
China
Contacts
Public ContactHong Li
The Second Affiliated Hospital of Army Medical University
Outcome results
None listed