Cancerous pain
Conditions
Interventions
Butorphanol+Dexmedetomidine:Intrathecal injection of butorphanol and dexmedetomidine
morphine:Intrathecal morphine injection
Sponsors
Shandong Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients with cancer pain (TNM stage ?~?) were intended to receive intrathecal analgesia; 2. Patients >=18 years old, regardless of gender; 3. Body mass index (BMI) 18.5-30kg /m^2; 4. American Society of Anesthesiologists (ASA) grade I to III; 5. The dose of oral morphine was >200 mg every 24 hours, and the visual analogue scale (VAS) score was >=4 points; 6. Patients and their families were informed of this study and signed informed consent;
Exclusion criteria
Exclusion criteria: 1. Patients who refuse to participate in the trial or who are uncooperative and unable to communicate; 2. Have a history of serious heart, brain, lung, liver, kidney and metabolic diseases; 3. Patients with a history of recovery from abnormal surgical anesthesia; 4. Electrocardiogram: heart rate 180mmHg and/or diastolic blood pressure >110mmHg in hypertensive patients, or <90/60mmHg in hypotensive patients; 7. People with neuromuscular system diseases or mental diseases; 8. Anemia patients; 9. Suspected abuse of narcotic analgesics or sedatives; 10. Predict that difficult airway may occur or have occurred; 11. Known allergy to emulsions and opioids; 12. Researchers consider it inappropriate to participate in this experiment;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure (BP), heart rate (HR), pulse oxygen saturation (SpO2), end expiratory partial pressure of carbon dioxide (PETCO2), respiratory rate (RR) ;Safety evaluation indicators: incidence of nausea, vomiting, itching, drowsiness, hypotension, hypoxemia, respiratory depression, apnea, bradycardia, etc.;Satisfaction rating;Spitzer quality of life index; | — |
Countries
China
Contacts
Public ContactLin Xiaowen
Shandong Provincial Hospital
Outcome results
None listed