Hereditary spastic paraplegia (HSP)
Conditions
Interventions
Test group:Intrathecal baclofen infusion therapy
Sponsors
The University of Hongkong - Shenzhen Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Clinically diagnosed as HSP; 2. At least two lower limb muscle groups have a Modified Ashworth Scale (MAS) score of >= 3; 3. Spasticity and the pain it causes seriously affect daily life and increase the difficulty of rehabilitation and care; 4. The effect of oral baclofen and other antispastic drugs is unsatisfactory or the patient cannot tolerate the related side effects; 5. Baclofen intrathecal test is effective and the patient is willing to receive ITB treatment.
Exclusion criteria
Exclusion criteria: 1. There are severe cognitive and mental disorders, and the patient is unable to cooperate with the treatment. 2. There are serious diseases of important organs such as the heart and lungs, and the patient cannot tolerate the treatment. 3. There is uncontrolled epilepsy, and the patient cannot tolerate the treatment. 4. There is an infection at the site of baclofen pump implantation. 5. Botulinum toxin local injection treatment was received within 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Spasm severity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Gait analysis;Sctivities of daily living; | — |
Countries
China
Contacts
Public ContactYongjie Li
The University of Hongkong - Shenzhen Hospital
Outcome results
None listed