Obesity
Conditions
Interventions
Telpotide group:None
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-70 years old, BMI>=37.5kg/m^2 2. Be eligible for Bariatric surgery (LSG) according to ASMBS/IFSO 2022 guidelines 3.Diagnosis of insulin resistance (HOMA-IR>2.69) or type 2 diabetes mellitus (HOMA-IR=FPG×FINS/22.5). 4. Signed the informed consent and had the complete follow-up data of our hospital.
Exclusion criteria
Exclusion criteria: 1. Confirmed diagnosis of non-obese type 1 diabetes mellitus. 2. Patients with gestational diabetes or certain specific types of diabetes. 3. Substance abuse, alcohol addiction, or uncontrolled psychiatric disorders. 4. Intellectual disability or cognitive immaturity impairing behavioral control. 5. Unrealistic expectations regarding surgical weight loss outcomes. 6. Unwillingness to accept potential surgical complications. 7. Inability to comply with postoperative dietary/lifestyle modifications (poor adherence). 8. Poor systemic condition precluding general anesthesia or surgery tolerance. 9. Personal/family history of Medullary Thyroid Carcinoma (MTC) or Multiple Endocrine Neoplasia type 2 syndrome (MEN2). 10. Known severe hypersensitivity to tirzepatide or any excipient. 11. Previous gastrointestinal surgery (gastric/duodenal) or metabolic/bariatric surgery. 12. Active gastrointestinal ulceration. 13. Untreated Helicobacter pylori infection. 14. History of severe cardiovascular/cerebrovascular diseases (myocardial infarction, stroke, etc.). 15. History of liver cirrhosis (Child-Pugh score >= Grade A). 16. History of chronic kidney disease (estimated Glomerular Filtration Rate [eGFR] = Grade A.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total Weight Loss Percentage (TWL%);Excess Weight Loss Percentage (EWL%);Gastrointestinal Quality of Life Index;Gastroesophageal reflux disease score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Remission Rate of Type 2 Diabetes [glycated hemoglobin (HbA1c) 30 days) complications;Operative Time;Mean hospitalization duration;Hospitalization days from surgery (operative day = D0) to discharge;SF-36 questionnaire;IWQOL-Lite-CT questionnaire; | — |
Countries
China
Contacts
Public ContactChen Yi
West China Hospital of Sichuan University
Outcome results
None listed