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Pathophysiological Alterations and Associated Mechanisms in Adolescent Idiopathic Scoliosis

Study on the Mechanisms Underlying Pathophysiological Changes in Spinal Disorders

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500114237
Enrollment
Unknown
Registered
2025-12-09
Start date
2025-12-20
Completion date
Unknown
Last updated
2025-12-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adolescent idiopathic scoliosis

Interventions

Observation group:No
Control group:No

Sponsors

The Fourth Medical Centre of the PLA General Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
8 Years to 18 Years

Inclusion criteria

Inclusion criteria: 1.Experimental group: (1)Adolescents aged 8–18 years diagnosed with idiopathic scoliosis (AIS) by a physician; (2)with normal body mass index (18.5–23.9 kg/m^2) and no associated complications; (3)All participants met surgical indications based on standing posterior-anterior radiographs showing a Cobb angle of the primary curve >40° and Risser sign >=3°, and underwent posterior scoliosis correction surgery. 2.Control group: (1)Patients with traumatic burst fractures, disc herniation, and spondylolisthesis who underwent posterior surgery by the same orthopaedic surgeon during the same period at the same hospital.

Exclusion criteria

Exclusion criteria: Patients with neurological disorders, musculoskeletal conditions, prior spinal surgery, tumours, or any other health issues or illnesses that may interfere with study results, as well as those refusing to participate in this research, shall be excluded.

Design outcomes

Primary

MeasureTime frame
Cobb angle;

Secondary

MeasureTime frame
Temperature;Entropy;

Countries

China

Contacts

Public ContactXuesong Zhang

The Fourth Medical Centre of the PLA General Hospital

475465429@qq.com+86 10 6684 8821

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026