Acute brain injury
Conditions
Interventions
Acute brain injury – Lymphatic dysfunction observation Cohort:None
Sponsors
Ruian People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 80 years, of any sex; 2. Having undergone routine cranial CT within 48 hours of admission, showing acute injury manifestations such as cerebral contusion, brain edema, ventricular compression, or subarachnoid hemorrhage; 3. Having completed cranial MRI within one month post-injury, including meningeal lymphatic vessel imaging sequences (e.g., 3D-FLAIR) with adequate image quality; 4. Having completed MRI follow-up within three months post-injury, including meningeal lymphatic vessel sequences to observe dynamic changes of MLVs; 5. For patients undergoing cranial surgery during clinical treatment with placement of cerebrospinal fluid (CSF) drainage catheters, multiple CSF samples may be collected postoperatively according to clinical procedures for the assessment of MLV regulatory factors; 6. For patients scheduled for elective procedures such as external ventricular drainage due to secondary hydrocephalus, who have completed standard MRI evaluation (including MLV sequences) preoperatively, meningeal tissue may be obtained intraoperatively for histological analysis without additional trauma; 7.Patients or their legally authorized representatives must understand the purpose and procedures of the study, provide written informed consent specifically for the research, voluntarily participate, and agree to cooperate with subsequent imaging follow-up.
Exclusion criteria
Exclusion criteria: 1. Age under 18 years, pregnant women, or patients with terminal illnesses; 2. Failure to complete CT evaluation within 48 hours of admission; 3. Presence of severe trauma at other body sites (Abbreviated Injury Scale >= 3); 4. Pre-existing chronic central nervous system diseases (e.g., Alzheimer’s disease, multiple sclerosis); 5. Presence of intracranial infectious diseases; 6. History of major central nervous system structural abnormalities or prior neurosurgery; 7. Immune deficiency or autoimmune disorders; 8. Severe systemic diseases (e.g., heart failure >= New York Heart Association class III, severe hepatic or renal insufficiency); 9. Inability to undergo MRI or presence of MRI contraindications (e.g., metallic implants, severe claustrophobia); 10. Refusal to sign the informed consent form or voluntary withdrawal from the study during the research process.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Radiomics Features of Meningeal Lymphatic Vessels (MLVs);CT-Based Cerebral Edema Evolution Curve; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cerebrospinal Fluid Biomarkers Reflecting MLV Function; | — |
Countries
China
Contacts
Public ContactJie Chen
Ruian People's Hospital
Outcome results
None listed