Dose-Response Relationship of Prophylactic Metaraminol for Hypotension Following General Anesthesia Induction in Elderly Patients

Prophylactic Metaraminol for Prevention of Hypotension in Elderly Patients Undergoing Anesthesia Induction: A Randomized Double-Blinded Dose-Response Study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500114230

Enrollment

Unknown

Registered

2025-12-09

Start date

2026-01-01

Completion date

Unknown

Last updated

2025-12-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypotension induced by general anesthesia

Interventions

group 1.0µg/kg/min:Patients are given a prophylactic infusion of metaraminol upon the initiation of general anesthesia induction, infusion rate of 1.0 µg/kg/min

group1.5µg/kg/min:Patients are given a prophylactic infusion of metaraminol upon the initiation of general anesthesia induction, infusion rate of 1.5 µg/kg/min

group 2.0µg/kg/min:Patients are given a prophylactic infusion of metaraminol upon the initiation of general anesthesia induction, infusion rate of 2.0 µg/kg/min

group2.5µg/kg/min:Patients are given a prophylactic infusion of metaraminol upon the initiation of general anesthesia induction, infusion rate of 2.5 µg/kg/min

Eligibility

Sex/Gender

All

Age

65 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Age: 65 - 85 years old; 2. ASA physical status: Class I - III; 3. Scheduled surgery under general anesthesia requiring laryngeal mask airway (LMA) insertion; 4. Body Mass Index (BMI): 18 - 30 kg/m²; 5. Having signed the informed consent form and voluntarily participating as a research subject.

Exclusion criteria

Exclusion criteria: 1. Patients undergoing cardiac surgery, patients receiving extracorporeal membrane oxygenation (ECMO) therapy, and patients undergoing abdominal or thoracic organ transplantation surgery; 2. Patients undergoing outpatient surgery (same-day surgery); 3. Patients who have received norepinephrine or other vasopressor therapy before the scheduled start of surgery; 4. Patients with severe heart disease; 5. Patients with systolic blood pressure (SBP) exceeding 180 mmHg or diastolic blood pressure (DBP) exceeding 110 mmHg during preoperative assessment; 6. Patients with a body mass index (BMI) of 30 kg/m²; 7. Patients allergic to any of the study drugs.

Design outcomes

Primary

Measure	Time frame
the incidence of hypotension;	—

Secondary

Measure	Time frame
Heart rate (HR) and oxygen saturation (SpO2) ;Serum creatinine value(Scr);Postoperative delirium;Length of hospital stay and the situation of readmission within 30 days;Troponin;	—

Countries

China

Contacts

Public ContactHejie Wang

Wenzhou Integrated Traditional Chinese and Western Medicine Hospita

283436774@qq.com+86 577 8891 0524

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026