Postoperative pain after abdominal surgery
Conditions
Interventions
Bupivacaine Liposome Group:Bupivacaine liposome 266 mg in 40 mL of 0.9% saline, administered via subcostal TAP block and lateral TAP block, 15 mL per point, total 60 mL
Ropivacaine group:0.25% ropivacaine hydrochloride, performing subcostal TAP block and lateral TAP block, 15 mL per point, total 60 mL
Ropivacaine-Dexamethasone Combination Group:0.25% ropivacaine hydrochloride with 5mg dexamethasone, performing subcostal TAP block and lateral TAP block, 15 mL per site, total 60 mL
Sponsors
Qingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Subjects scheduled for abdominal surgery under general anesthesia, with an expected surgery duration of 1 to 6 hours; (2) Age >=18 years, of any gender; (3) ASA I–III; (4) No mental illness or cognitive impairment; (5) Informed of the study contents before enrollment and voluntarily signed the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Long-term use of analgesic drugs; (2) History of chronic pain or neurological disorders; (3) Severe cardiac, hepatic, renal, or respiratory dysfunction; (4) Coagulation disorders; (5) Infection at the puncture site or systemic infection; (6) Allergy to anesthetic drugs or to the study drug and its excipients, or previous severe adverse reactions; (7) Recent history of radiotherapy or chemotherapy; (8) Pregnant or breastfeeding women; (9) Participation in another clinical trial within the past 4 weeks; (10) Any unstable condition or situation that, in the investigator's judgment, could jeopardize the safety of the subject or their compliance with the study.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Postoperative pain medication usage;Levels of pain mediators and stress hormones;Postoperative recovery condition;Occurrence of adverse reactions;Patient satisfaction; | — |
Primary
| Measure | Time frame |
|---|---|
| Pain Visual Analog Scale; | — |
Countries
China
Contacts
Public ContactShoushi Wang
Qingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Hospital)
Outcome results
None listed