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The Impact of Different Enteral Nutrition Infusion Rate Escalation Strategies on Refeeding Syndrome in Critically Ill Patients and the Underlying Metabolic Mechanisms

The Impact of Different Enteral Nutrition Infusion Rate Escalation Strategies on Refeeding Syndrome in Critically Ill Patients and the Underlying Metabolic Mechanisms

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500114224
Enrollment
Unknown
Registered
2025-12-09
Start date
2025-12-31
Completion date
Unknown
Last updated
2025-12-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Refeeding Syndrome,RFS

Interventions

Fast Group(72 h to Target):Day 1: Administer 50% of the target caloric intake. Day 2: Administer 75% of the target caloric intake. Day 3 onward: Maintain 100% of the target caloric intake.
Medium Group (5 d to Target):Fifty percent of the target caloric intake is administered on Day 1 and Day 2, increasing to eighty-three percent on Day 3 and Day 4, with full caloric targets (100%) deli
Slow Group(7 d to Target):During the initial three days, patients are administered 50% of the target caloric requirement daily. On the fourth day, this is increased to 70% of the target caloric intake

Sponsors

Second Hospital of Shanxi Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Meets critical illness criteria 2. Age >=18 years 3. First-time ICU admission 4. No enteral or parenteral nutritional support within one week prior to ICU admission 5. Tolerance to enteral nutrition with expected duration >=7 days 6. Anticipated ICU stay >=7 days 7. Nutritional Risk Screening 2002 (NRS 2002) score >=3 8. Written informed consent obtained from the patient or legal guardian

Exclusion criteria

Exclusion criteria: 1. End-stage malignant disease; 2. Extremely high risk of refeeding syndrome (BMI 15 days / >20% body weight loss); 3. Other hypophosphatemia risk factors (dialysis / parathyroid surgery / tumor lysis / phosphate-binding agents for renal replacement therapy); 4. Pregnancy / lactation / severe immunodeficiency; 5. Patients diagnosed with or previously having refeeding syndrome; 6. Diabetic ketoacidosis complications.

Design outcomes

Primary

MeasureTime frame
The incidence rate of refeeding syndrome;

Secondary

MeasureTime frame
serium inorganic phosphorus;The incidence of gastrointestinal intolerance;Energy and Protein Target Achievement Rate;serum potassium;Blood magnesium;

Countries

China

Contacts

Public ContactWang Chujun

Second Hospital of Shanxi Medical University

1135622462@qq.com+86 183 3479 6305

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026