Acute spinal cord injury
Conditions
Interventions
Experimental Group:0.9 % sodium chloride solution 100ml compatibility methylprednisolone 40mg ivgtt Q12h, continuous use of 7 days
Control group:0.9 % sodium chloride solution 100ml ivgtt Q12h, continuous use for 7 days
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Acute spinal cord injury in the neck or chest; 2. The time from injury to hospital admission is less than 24 hours; 3. All patients underwent spinal canal decompression surgery. 4. No surgery-related complications occurred (such as internal fixation complications, intraspinal hematoma, iatrogenic spinal cord injury, etc.); 5. The patient's ASIA neurological function classification at admission was B, C, or D.
Exclusion criteria
Exclusion criteria: 1.Pregnant women; 2. People allergic to Methylprednisolone; 3. There were already diseases such as pulmonary infection and gastrointestinal bleeding before admission; 4. Hormone drugs had been used in other institutions before admission; 5. Patients who had obvious neurological dysfunction or spinal cord function impairment before spinal cord injury; 6. There are related diseases that have a significant impact or may affect the recovery of neurological function as the disease progresses; 7. Patients with multiple injuries such as severe traumatic brain injury.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The change in the ASIA neurological function score of the patient 12 months after injury compared with the baseline (at admission); | — |
Secondary
| Measure | Time frame |
|---|---|
| The change in the ASIA neurological function grade of the patient 12 months after injury compared to the baseline (at admission);The changes in the ASIA neurological function score of the patient from baseline (at admission) at 3 and 6 months after injury and the neurological function Change value of function level;The incidence of perioperative complications; | — |
Countries
China
Contacts
Public ContactLiu Zhili
The First Affiliated Hospital of Nanchang University
Outcome results
None listed