Postoperative cognitive dysfunction
Conditions
Interventions
Case group:None
Control group:None
Sponsors
Guangdong Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
65 Years to 95 Years
Inclusion criteria
Inclusion criteria: 1. Age >=65 years 2.American Society of Anesthesiologists (ASA) classification I–III 3. Preoperative blood and urine tests, liver and kidney function, and blood electrolytes are within normal range 4. The patient has a gastrointestinal tumor and agrees to the anesthesia method of combined spinal and general anesthesia
Exclusion criteria
Exclusion criteria: 1. Pre-operative history of defined neurological or psychiatric disorders, or long-term use of sedatives or antidepressants; 2. Presence of contraindications for spinal puncture; 3. History of alcohol abuse or substance dependence; 4. Severe visual or auditory impairment; 5. History of haemorrhagic or embolic cerebrovascular disease; 6. Inability to cooperate with cognitive function testing.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prevalence of POCD;Differentially Expressed Spectrum of Cerebrospinal Fluid Metabolites; | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation Analysis of Metabolites with Post-Operative Cognitive Disorder; | — |
Countries
China
Contacts
Public ContactShi yongyong
Guangdong Provincial Hospital of Traditional Chinese Medicine
Outcome results
None listed