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The Impact of Pylorus-Preserving Versus Pylorus-Resecting Laparoscopic Pancreaticoduodenectomy on the Incidence of Marginal Ulcers- A Prospective Randomized Controlled Study

The Impact of Pylorus-Preserving Versus Pylorus-Resecting Laparoscopic Pancreaticoduodenectomy on the Incidence of Marginal Ulcers- A Prospective Randomized Controlled Study - The Incidence of Marginal Ulcers after Laparoscopic Pylorus-Preserving or Pylorus-Resecting Pancreaticoduodenectomy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500114193
Enrollment
Unknown
Registered
2025-12-09
Start date
2025-12-15
Completion date
Unknown
Last updated
2025-12-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pancreatic Head or Periampullary Diseases

Interventions

The Laparoscopic Pylorus-Preserving Pancreaticoduodenectomy (LPPPD) Group:Pylorus-Preserving
The Laparoscopic Pylorus-Resecting Pancreaticoduodenectomy (LPPPD) Group:Pylorus-Resecting

Sponsors

West China Hospital of Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1) Patients with preoperative CT or MRI suggesting pancreatic head or periampullary diseases who are eligible for laparoscopic pancreaticoduodenectomy (with or without pylorus preservation); 2) Age over 18 years and not exceeding 85 years; 3) Able to comply with the research plan and other protocol requirements; 4) Voluntarily agree to participate as a subject and provide written informed consent.

Exclusion criteria

Exclusion criteria: 1) Patients with preoperative examinations indicating significant surgical contraindications; 2) Patients and/or their legal representatives explicitly refuse surgery or refuse a specific minimally invasive surgical approach; 3) Patients requiring concurrent resection of other solid or hollow organs (excluding portal vein-superior mesenteric vein resection and reconstruction); 4) Patients with a history of prior gastrectomy or other surgeries involving gastrectomy; 5) Patients with direct invasion of the pylorus or stomach, patients with positive peripyloric lymph nodes, or patients with other conditions necessitating pyloric resection; 6) Patients otherwise deemed unsuitable candidates for laparoscopic pancreaticoduodenectomy.

Design outcomes

Primary

MeasureTime frame
The Incidence of Marginal Ulcers;—

Secondary

MeasureTime frame
Incidence of Delayed Gastric Emptying;Incidence of Clinically Relevant Postoperative Pancreatic Fistula (CR-POPF) ;Incidence of Marginal Ulcers Perforation;Incidence of Major Complications (Clavien-Dindo Grade III-V);The EORTC QLQ-C30 (version 3) Quality of Life Questionnaire;—

Countries

China

Contacts

Public ContactPeng Bing

West China Hospital of Sichuan University

pengbing84@hotmail.com+86 189 8060 1481

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026