?Outcome of Frozen Embryo Transfer
Conditions
Interventions
Letrozole group:Starting on day 3 of the menstrual cycle, administer letrozole 2.5 mg orally once daily for 4 days. Five days later, perform dynamic ultrasound monitoring of follicular development, an
Natural Cycle Group:Based on the length of the menstrual cycle, transvaginal ultrasound monitoring is initiated on day D8–D11, followed by ultrasound examinations every 1–3 days according to the rate
Sponsors
Beijing Chao-Yang Hospital, Capital Medical University
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Regular menstrual cycles (defined as 21–35 days); 2. Aged 20–40 years; 3. Scheduled to undergo frozen-thawed single blastocyst transfer (including IVF/ICSI cycles); 4. Normal-range BMI (18.5–24 kg/m^2); 5. Availability of >=1 cryopreserved blastocyst(s) with Gardner morphology score >=4BC from IVF/ICSI cycles;
Exclusion criteria
Exclusion criteria: 1. History of >=2 previous embryo transfers without achieving clinical pregnancy; 2. Embryos scheduled for thawing derived from oocyte cryopreservation or subjected to repeated freeze-thaw cycles; 3. Untreated uterine pathologies affecting endometrial receptivity (e.g., uterine malformations, submucosal myomas >=1.5 cm, adenomyosis with junctional zone >=7 mm, or intrauterine adhesions); 4. Untreated ultrasonographically visible hydrosalpinx (defined as fluid-filled dilated fallopian tubes >=10 mm); 5. Previous cycle cancellation due to inadequate endometrial thickness (<7 mm) during frozen embryo transfer preparation; 6. Documented immune disorders (e.g., antiphospholipid syndrome, systemic lupus erythematosus with positive anti-dsDNA, active rheumatic diseases); 7. Parental chromosomal abnormalities (excluding benign polymorphisms).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ongoing pregnancy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Early miscarriage;Biochemical pregnancy;Clinical pregnancy;Ectopic pregnancy; | — |
Countries
China
Contacts
Public ContactPan Ye
Beijing Chao-Yang Hospital, Capital Medical University
Outcome results
None listed