Ocular Surface Diseases (Corneal Stromal Defect)
Conditions
Interventions
Hydrogel Repair Group:Repairing defective corneal stroma with hydrogel
Sponsors
Eye Hospital of Shandong First Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Patients with corneal stromal defects, including those caused by trauma or following infectious lesion excision, with a residual corneal thickness of =400 microns in the defect area. 2. Patients aged 18 to 85 years (inclusive) at the time of consent acquisition, regardless of gender. 3. Patients capable of providing written informed consent voluntarily to participate in the study
Exclusion criteria
Exclusion criteria: 1. Patients with keratoconjunctival diseases of unknown etiology. 2. Patients with severe ocular surface diseases, including severe dry eye, symblepharon, corneal neovascularization, etc. 3. Patients with systemic infectious diseases (positive for bacteria, fungi, HBV, HCV, HIV, TP, or other viruses). 4. Patients with systemic autoimmune diseases, such as rheumatoid arthritis, Sjögren's syndrome, graft-versus-host disease, etc. 5. Subjects with other uncontrolled ocular diseases in the study eye. 6. Patients with failure of major organ functions or other severe systemic conditions, such as cardiac insufficiency; severe diabetes (fasting blood glucose >8 mmol/L despite glucose-lowering measures); uncontrolled hypertension stage II or above (blood pressure >160/100 mmHg despite medication); history of malignant tumor (within 5 years); severe immunodeficiency, etc. 7. Subjects with psychiatric disorders that may interfere with treatment or evaluation. 8. Pregnant or breastfeeding women, or women planning to become pregnant during the clinical study period. 9. Subjects deemed unsuitable for participation in this clinical trial by the investigator. 10. Patients unable to complete follow-up visits.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Corenal Thickness;Vision;IOP; | — |
Secondary
| Measure | Time frame |
|---|---|
| Corneal Topography;Corneal Epithelial Healing ; | — |
Countries
China
Contacts
Public ContactWeiyun Shi
Eye Hospital of Shandong First Medical University
Outcome results
None listed