colorectal cancer
Conditions
Interventions
Nalbuphine group:Intravenous injection of Nalbuphine, Nalbuphine patient-controlled analgesia pump for postoperative analgesia.
Normal Saline Group:Intravenous injection of Normal Saline
Sponsors
The First Affiliated Hospital of Shantou University Medical College
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 65 years; 2. BMI 18-28 kg/m^2; 3. Preoperative diagnosis of colon cancer, planned for laparoscopic radical surgery for colon cancer; 4. ASA grade I-III, able to tolerate surgery; 5. Patient or their legal representative has signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Preexisting chronic pain or long-term use of analgesics before surgery; 2. Allergy to nalfurafine or any components of the investigational drug; 3. Severe cardiopulmonary dysfunction before surgery (including severe aortic stenosis, NYHA class III-IV heart failure; left ventricular ejection fraction less than 50%, severe pneumonia, pulmonary edema, acute exacerbation of COPD, etc.), liver and kidney dysfunction, or other comorbidities; 4. Severe cognitive impairment or psychiatric disorders preventing completion of scale assessments; 5. Patients who refuse to participate or have poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative 24h, 48h, 72h QoR-15 scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Occurrence of respiratory depression;Occurrence of postoperative delirium;other adverse events;Nausea and Vomiting Score;Anesthesia-related information (type of anesthesia, medications used for anesthesia, sedation, and analgesia); Surgery-related information (duration of surgery, intraoperative blood loss, intraoperative urine output);Pain scores: Resting and activity VAS scores at 2h, 24h, 48h, and 72h postoperatively;Sedation scores: Ramsay Sedation Scale scores at 2h, 24h, 48h, and 72h postoperatively.;Itching Severity Scale; | — |
Countries
China
Contacts
Public ContactSun Wei
the First Affiliated Hospital of Shan Tou University Medical College
Outcome results
None listed