Hypertensive Disorders of Pregnancy
Conditions
Interventions
Control Group:Standard care
Experimental Group:Precision Blood Pressure Management
Sponsors
Guangzhou Women and Children's Medical Center, Guangzhou Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Aged >=18 years; 2.Singleton pregnancy with a gestational age =140 mmHg and/or diastolic blood pressure >=90 mmHg detected before 20 weeks of gestation, without significant exacerbation during pregnancy or presenting as acute severe hypertension; 4.Planning to receive antenatal care and deliver at our hospital, with good adherence and the ability to complete scheduled follow-up assessments; 5.Agrees to participate in the study and signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Fetal chromosomal abnormalities and structural abnormalities; 2.Multiple pregnancies; 3.Patients who are allergic to antihypertensive drugs or are prohibited from using such drugs for other reasons; 4.Unable to complete ABPM or USCOM assessments, or refusing medication intervention; 5.Women with poor compliance and cannot have regular pregnancy check-ups; 6.Presence of psychiatric disorders or cognitive impairment that prevents effective communication with the study team.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of preeclampsia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Severe hypertension (systolic BP >160 mmHg and/or diastolic BP =110 mmHg);Eclampsia;HELLP syndrome;liver dysfunction (ALT or AST >70 IU/L), renal dysfunction (creatinine >150 µmol/L), thrombocytopenia (<100×10?/L), stroke, pulmonary edema, placental abruption, and uteroplacental dysfunction ( fetal growth restriction, abnormal umbilical artery blood flow, or intrauterine fetal death).;birth weight, incidence of small for gestational age (SGA), preterm birth rate (gestational age < 37 weeks ), and NICU admission rate.;Total dosage and types of antihypertensive drugs; | — |
Countries
China
Contacts
Public ContactJiang Yanmin
Guangzhou Women and Children's Medical Center, Guangzhou Medical University
Outcome results
None listed