Oral mucosal immunity
Conditions
Interventions
EXperimental group:Temporary engineered multiantigen particle based sublingual tablet for the sublingual mucosal area intervention
Sponsors
The Affiliated Hospital of Stomatology, Chongqing Medical University
Eligibility
Sex/Gender
All
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Volunteers recruited clinically, aged 20-50, with no gender restrictions. 2. Subjects voluntarily sign an informed consent form, with expected good compliance.
Exclusion criteria
Exclusion criteria: 1. Individuals who have previously undergone oral surgery or have dental restorations that may interfere with the evaluation of the study parameters. 2. Hypertensive patients with a systolic blood pressure > 180 mmHg or diastolic blood pressure > 110 mmHg. 3. Patients with systemic diseases (autoimmune diseases, malignant tumors, diabetes, heart failure due to cardiac disease, myocardial infarction within the last 6 months, angina symptoms within the last 6 months, congenital heart disease, etc.). 4. Individuals currently using nonsteroidal anti-inflammatory drugs (NSAIDs), bisphosphonates, or corticosteroids. 5. Individuals with bleeding tendency or coagulation dysfunction (white blood cell count WBC<3.0 * 10 ^ 9/L or platelet count PLT<60 * 10 ^ 9/L); 6. HIV or hepatitis B virus carriers. 7. Pregnant or breastfeeding women, or women planning to become pregnant within 6 months or using estrogen-based contraception. 8. Patients with a history of alcohol abuse, intravenous drug addiction, mental disorders or intellectual disabilities, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vital signs, including body temperature, blood pressure and heart rate;Oral mucosal examination;Complete blood count and blood biochemical parameters;Adverse events considered related to administration of engineered multiantigen particle based sublingual tablet; | — |
Secondary
| Measure | Time frame |
|---|---|
| S. aureus-specific salivary sIgA level;Submandibular lymph-node ultrasound examination; | — |
Countries
China
Contacts
Public ContactXu Junji
The Affiliated Hospital of Stomatology, Chongqing Medical University
Outcome results
None listed