Adolescents non-suicidal self-injury behavior, suicidal attempt, suicidal behavior
Conditions
Interventions
Drug Treatment group:Antipsychotic Drugs,antidepressants, mood stabilizers, etc.
MST group:Combining drug therapy with magnetic seizure therapy
Sponsors
Nanjing Brain Hospital
Eligibility
Sex/Gender
All
Age
12 Years to 25 Years
Inclusion criteria
Inclusion criteria: 1.Diagnosis of Mood disorders, bipolar disorder, depressive disorder according to ICD-11 diagnostic criteria; 2.Diagnosis of non-suicidal self-injury, suicide attempts, suicidal behavior according to ICD-11 diagnostic criteria; 3.Age over 12 years old, under 25 years old, gender unlimited; 4.Consistent with written informed consent; 5.Right-handedness;
Exclusion criteria
Exclusion criteria: 1.Patients with severe physical diseases such as brain organic diseases, cardiovascular diseases, tumors, etc; 2.Abnormal laboratory tests affect the efficacy of the study or affect the safety of the subjects; 3.Intracranial metal foreign matters, patients with cardiac pacemakers, cochlear implants, etc; 4.Pregnant, lactating women or those planning to become pregnant during the trial; 5.Patients who had received ECT/MST within 3-6 months, or who had previously received ECT/MST were ineffective; 6.Other situations that the researchers believe are not suitable for participating in the clinical trial;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Barratt Impulsiveness Scale, BIS-11;MATRIC Consensus Cognitive Battery, MCCB;Hamilton depression scale, HAMD;Hamilton anxiety scale, HAMA;Positive and Negative Syndrome Scale score, PANSS;Difficulties in emotion regulation scale, DERS;Ottawa self-injury inventory;Autobiographical Memory Test, AMT; | — |
Secondary
| Measure | Time frame |
|---|---|
| hormone combination ( estradiol, testosterone, progesterone, follicle stimulating hormone, luteinizing hormone );magnetoencephalogram;Changes of brain structure and functional imaging;CRP;IL-1ß, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-17, IFN-?, TNF-a, IFN-a;Treatment Emergent Symptom Scale, TESS;S-100 protein;blood cells analysis; | — |
Countries
China
Contacts
Public Contactyuxiu sui
Nanjing Brain Hospital
Outcome results
None listed