patients with traumatic fractures
Conditions
Interventions
Group L:Hydrochloride esketamine injection 0.5 mg/kg, diluted with physiological saline to 48ml, infused at a rate of 2ml/h for 24 hours.
Group H:Hydrochloride esketamine injection 0.75 mg/kg, diluted with physiological saline to 48ml, infused at a rate of 2ml/h for 24 hours.
Group C:48ml of physiological saline was infused at a rate of 2ml/h for 24 hours
Sponsors
Jiangxi Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-64 years old; 2. Diagnosed with unilateral traumatic lower limb fracture (femur or tibiofibula), and scheduled for open reduction and internal fixation; 3. American Society of Anesthesiologists (ASA) Physical Status Classification I-III; 4. A HAMD-17 score of =7 at admission; 5. Body mass index between 18-35 kg/m²; 6. Voluntary participation and signing of a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Known allergy to esketamine or any anesthetic agent used in this study; 2. Individuals with a diagnosed history of mental illness or long-term use of antipsychotic or antidepressant medications; 3. Individuals with uncontrolled refractory hypertension, severe cardiovascular or cerebrovascular diseases, glaucoma, or sleep apnea syndrome; 4. Individuals with cognitive impairments or those unable to understand and complete the research questionnaire; 5. Pregnant or breastfeeding women.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Pain score;the level of sedation;The number of PCA compressions;The incidence of adverse reactions; | — |
Primary
| Measure | Time frame |
|---|---|
| the HAMD score;the total postoperative sufentanil consumption; | — |
Countries
China
Contacts
Public ContactLiu Zhongyu
Jiangxi Provincial People's Hospital
Outcome results
None listed