The effect of neutrophil heterogeneity on ineffective reperfusion after large vessel occlusion stroke based on single-cell sequencing

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2500114149

Enrollment

Unknown

Registered

2025-12-08

Start date

2024-03-06

Completion date

Unknown

Last updated

2025-12-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute large vessel occlusion ischemic stroke

Interventions

cardioembolic stroke:None

intracranial atherosclerotic stenosis:None

Eligibility

Sex/Gender

All

Age

55 Years to 75 Years

Inclusion criteria

Inclusion criteria: 55 to 75 years old, with large vessel occlusion (internal carotid artery, middle cerebral artery M1, anterior cerebral artery A1, basilar artery, posterior cerebral artery P1), within 24 hours of onset, the ischemic penumbra was quantitatively evaluated with Tmax>6s and rCBF1.8, infarcted core15ml.

Exclusion criteria

Exclusion criteria: Hemorrhagic stroke, tumor, infection, autoimmune disease.

Design outcomes

Primary

Measure	Time frame
Changes in gene expression of neutrophils;	—

Secondary

Measure	Time frame
Blood Routine Test;	—

Countries

China

Contacts

Public ContactXinxin Huang

Zhongda Hospital Southeast Universiy

916705395@qq.com+86 18351997306

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026