Pancreatic cancer
Conditions
Interventions
Gold Standard:Final PNI status (positive/negative) was obtained based on blinded review (H&E and immunohistochemical sections) by a committee of expert pathologists.
Index test:Imaging omics model based on AiCE low-dose CT
Sponsors
China-Japan Friendship Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients with pancreatic ductal adenocarcinoma (PDAC) confirmed by clinical pathology; 2. Radical surgical resection of pancreatic cancer; 3. Complete AiCE-based low-dose enhanced CT scan before neoadjuvant therapy; 4. AiCE-based low-dose enhanced CT scan was completed within one week before surgery after neoadjuvant treatment; 5. PNI pathological analysis was completed by biopsy specimens before neoadjuvant treatment; 6. Detect tumor markers such as carcinoembryonic antigen (CEA), carboembryonic antigen 19-9 within 1 week before the operation; 7. Age >=18 years old.
Exclusion criteria
Exclusion criteria: 1. Patients with contraindications to enhancing CT examinations; 2. Those who have mental illness or other reasons cannot cooperate with the examination; 3. The CT image quality is poor, and there are serious artifacts, etc.; 4. Refusal to surgically remove the tumor; 5. The pathological type is not PDAC, such as neuroendocrine tumors, etc. 6. Neoadjuvant chemoradiation or other drug-based treatments for tumors were performed before the examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The area under the receiver operating characteristic curve (AUC) ;Accuracy;Specificity;Sensitivity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Stability of the model; | — |
Countries
China
Contacts
Public ContactYue Lin
China-Japan Friendship Hospital
Outcome results
None listed