Esophagectomy
Conditions
Interventions
Neoadjuvant therapy group:Neoadjuvant therapy (determined as necessary by medical or surgical oncologists according to guidelines
no restrictions on the choice of neoadjuvant drugs).
No neoadjuvant therapy group:No neoadjuvant therapy (determined as unnecessary by medical or surgical oncologists according to guidelines).
Sponsors
The Cancer Hospital, Shantou University Medical College
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Preoperative diagnosis of esophageal cancer, intending to perform radical esophagectomy. 2. ASA Classification I-IV.
Exclusion criteria
Exclusion criteria: 1. Open surgery; 2. Recurrence after non-surgical treatment of esophageal cancer; 3. Presence of other malignant tumors or severe mental illness; 4. Severe cardiopulmonary insufficiency; 5. Severe liver or kidney dysfunction; 6. History of adverse reactions to sedation or general anesthesia; 7. Allergy to opioids; 8. Allergy to tecresol or propofol; 9. Allergy to rocuronium bromide; 10. Long-term use of medications known to synergistically interact with propofol or HSK3486; 11. Preoperative identification of potential difficult airway.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Average dose of ciprofol (mg/kg/h); | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to achieve BIS <= 60 after drug administration;Time to loss of consciousness after propofol injection;Heart rate and blood pressure at baseline, after drug administration, immediately after intubation, and 5 min after intubation;Other secondary indicators: total consumption of propofol and propofol consumption; number of intraoperative adjustments of propofol infusion rate; incidence of postoperative nausea and vomiting; time from drug discontinuation to awakening; time from drug discontinuation to eyelid movement in response to verbal stimulation; remifentanil consumption; atracurium consumption; norepinephrine consumption; incidence of MAP decrease by 30% or below 65 mmHg after drug administration but before intubatio; | — |
Countries
China
Contacts
Public ContactSu Zegeng
Cancer Hospital Of Shantou University Medical College
Outcome results
None listed