Evaluating the role of resilient bone collagen and collagen membranes in post-extraction bone healing of mandibular third molars

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500114135

Enrollment

Unknown

Registered

2025-12-08

Start date

2025-12-08

Completion date

Unknown

Last updated

2025-12-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The distal bone defect of the mandibular second molar after the extraction of the mandibular impacted third molar

Interventions

control group:none

Resilient bone collagen group:After the extraction of the mandibular third molars, resilient bone collagen was implanted

Resilient bone collagen combined with collagen membrane group:After the extraction of the mandibular third molars, resilient bone collagen and collagen membranes were implanted

Eligibility

Sex/Gender

All

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. Age: 18-45 years old, gender not limited; 2. No underlying diseases; 3. The mandibular third molars are partially impacted (partially covered by the gums or bone tissue); 4. The depth of bone defect in the distal middle of the mandibular second molar measured by CBCT before the operation was greater than 4mm;

Exclusion criteria

Exclusion criteria: 1. There are pulp lesions and/or insufficient pulp treatment in adjacent mandibular second molars, or tooth splitting, or the degree of loosening is grade 3, or the prognosis is poor in the comprehensive clinical and imaging evaluation; 2. Metal crowns or silver-mercury alloy restorations on adjacent mandibular second molars can interfere with imaging evaluations; 3. The patient has a history of uncontrolled diabetes, blood disorders, alcohol abuse, drug abuse or heavy smoking. Pregnant women or those undergoing orthodontic treatment; Acute inflammatory period or any other surgical contraindications;

Design outcomes

Primary

Measure	Time frame
The depth of bone defect in the distal middle of the mandibular second molar;	—

Secondary

Measure	Time frame
Interincisor Distance;The volume of bone in the tooth extraction socket;The probing depth, attachment loss and bleeding index of the mandibular second molar;degree of swelling;pain;	—

Countries

China

Contacts

Public ContactXiangliang Xu

Peking University Hospital of Stomatology

Kqxxl@126.com+86 10 82195398

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026