late-onset sepsis in preterm infants
Conditions
Interventions
Immediate blood sampling group:none
Delayed observation group:none
Sponsors
Anhui Medical University First Affiliated Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Post-menstrual age > 72 h; 2. At least one non-critical clinical finding as defined in the 2025 Expert Consensus on Neonatal Sepsis for Primary-Care Institutions; 3. Signed informed consent from the legal guardian.
Exclusion criteria
Exclusion criteria: Exclusion Criteria (any one disqualifies) 1. Critical illness mandating immediate resuscitation: a. Apnea requiring invasive ventilation; b. Shock requiring cardiopulmonary resuscitation or vasoactive drugs; c. Clinical seizures. 2. Established major risk factors for late-onset sepsis: a. Current central venous access (e.g., PICC, UVC); b. Ongoing invasive mechanical ventilation; c. Surgery within the preceding 7 days. Antibiotic status: 3. a. No active infection but receiving targeted antibiotic prophylaxis; b. Active infection under therapeutic antibiotic treatment. 4. Severe congenital malformation(s) or decision to withhold/withdraw care.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 7-day missed diagnosis rate of LOS in delayed blood sampling group; | — |
Secondary
| Measure | Time frame |
|---|---|
| Type of blood sampling decision (immediate/delayed);Final diagnosis of late-onset sepsis (LOS);Dynamic change score of non-critical symptoms;Pathogen distribution of LOS;Pathogen drug resistance spectrum;Antibiotic usage rate (immediate vs delayed group); | — |
Countries
China
Contacts
Public ContactWang Yang
Anhui Medical University First Affiliated Hospital
Outcome results
None listed