Pediatric Respiratory Tract Infections
Conditions
Interventions
Sponsors
Department of Pediatrics, Xijing Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 14 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria for Children with Respiratory Tract Infections (100 cases): Aged 0-14 years, regardless of gender. Meeting the diagnostic criteria for either pediatric acute bronchitis or pneumonia. Presence of a respiratory pathogen. 1. Inclusion Criteria for Acute Bronchitis (50 cases): Community-acquired infection, including infections with a definite incubation period that manifest after hospital admission within the incubation period. (1) Clinical Manifestations: Most patients initially present with symptoms of an upper respiratory tract infection, followed by the onset of cough. The cough is initially dry but intensifies within 1-2 days, with increased sputum production that progresses from mucoid to mucopurulent. Severe coughing may lead to nausea, vomiting, and pain in the chest and abdominal muscles. Fever is uncommon. Systemic symptoms typically resolve within 3-5 days, but the cough may persist for a longer duration. (2) Physical Examination Findings: Mostly unremarkable, though coarse breath sounds may occasionally be heard. (3) Auxiliary Examinations: Complete blood count is mostly normal, with possible lymphocytosis. If a bacterial co-infection is present, the total white blood cell count and neutrophil proportion may increase. Chest X-ray findings are negative. 2. Inclusion Criteria for Pneumonia (50 cases): Community-acquired infection, including infections with a definite incubation period that manifest after hospital admission within the incubation period, AND presenting with two or more of the following clinical features: (1) Clinical Symptoms: New onset or worsening of existing respiratory symptoms such as cough and sputum production; fever; tachypnea; grunting; cyanosis. (2) Physical Signs: Fixed fine crackles (rales) in the lungs and/or signs of lung consolidation. Nasal flaring and/or chest wall retractions may be present. (3) Chest Imaging: Chest X-ray shows evidence of consolidation in a lobe or segment.
Exclusion criteria
Exclusion criteria: Exclusion Criteria for Children with Respiratory Tract Infections: Known or suspected active tuberculosis; Severe comorbidities (e.g., chronic lung disease, significant cardiovascular disease, malignancy, or renal/hepatic disease); Primary immunodeficiency; Acquired Immunodeficiency Syndrome (AIDS) or use of immunosuppressive drugs prior to hospitalization; Lack of eligible or complete data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Respiratory microbiota detection;Gut microbiota detection;Serum metabolomics detection;Fecal metabolomics detection; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cytokine detection;Flow cytometry analysis; | — |
Countries
China
Contacts
Public ContactSun Xin
The First Affiliated Hospital of Air Force Medical University
Outcome results
None listed