Postoperative delirium (POD)
Conditions
Interventions
Dexmedetomidine nasal spray group:Dexmedetomidine nasal spray*3 times
Normal saline group:Normal saline nasal spray*3 times
Sponsors
Shanghai General Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Patients with long bone fractures of the lower extremities that undergo elective surgical treatment, including femur, tibia, fibula, or multiple combined fractures. 2. Age >= 65 years old. 3. ASA grade I~III. 4. No cognitive dysfunction or delirium at present. 5. Voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients who are expected to have surgery later than 16:00 on the day of surgery. 2. Combined fractures in other parts of the lower limbs, such as head, chest, upper limbs, pelvis, etc. 3. Suffering from severe rhinitis and nasal deformity. 4. Patients with diagnosed neurodegenerative diseases, history of mental illness, inability to communicate normally, and language disorders. 5. Those who have a history of allergy or resistance to alpha2 receptor agonists, or who are using long-acting alpha2 agonists. 6. Those with a history of acute cerebrovascular disease (stroke or cerebral hemorrhage within 6 months). 7. Those who are admitted to the hospital with an electrocardiogram showing 2° or 3° atrioventricular block or bradycardia (heart rate < 50 bpm). 8. Already enrolled in other clinical investigators. 9. Patients who require ventilator treatment after surgery. 10. Other situations that the investigator judges does not meet the requirements of the study according to the specific situation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Delirium incidence within 5 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep quality;Postoperative rehabilitation and the occurrence and outcome of complications;Anesthesia and blood indicators;quality of early postoperative recovery;intraoperative BIS and EEG of the patient.;occurrence of adverse events.;Time from surgery to discharge and cost;pain; | — |
Countries
China
Contacts
Public ContactHuang Lina
Shanghai General Hospital
Outcome results
None listed